Harmful Effects of Increased LDLR Expression in Mice With HumanAPOE*4But NotAPOE*3
نویسندگان
چکیده
منابع مشابه
Harmful effects of increased LDLR expression in mice with human APOE*4 but not APOE*3.
OBJECTIVE Increased expression of the low-density lipoprotein receptor (LDLR) is generally considered beneficial for reducing plasma cholesterol and atherosclerosis, and its downregulation has been thought to explain the association between apolipoprotein (apo) E4 and increased risk of coronary heart disease in humans. METHODS AND RESULTS Contrary to this hypothesis, doubling Ldlr expression ...
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ژورنال
عنوان ژورنال: Arteriosclerosis, Thrombosis, and Vascular Biology
سال: 2004
ISSN: 1079-5642,1524-4636
DOI: 10.1161/01.atv.0000094963.07902.fb